Blog

Neurophysiological Markers of the “Self” in Psychosis: Insights from the SUCEDE Project: As part of the ongoing dissemination of the SUCEDE project, we are sharing a synthesis of our current findings focused on the cerebral substrates of agency recognition and its alteration across the psychotic spectrum. Access the Audiovisual Document: https://youtu.be/MB5cFJMVYHY

Neuroconnectivity Analysis in Psychosis: Implications of PCI Results in the Delineation of Biotypes The session addressed the methodological application of the Perturbational Complexity Index (PCI) as an objective marker for patient stratification within the psychotic spectrum. The relevance of this research lies in the urgent need to transition from a symptomatic nosology toward an etiopathogenic…

Video in YouTube (in Spanish) 🧠 The Root of the Problem: Disturbance of the Minimal SelfFor more than a century, figures like Kraepelin and Bleuler already pointed out that the core of psychosis is not just the striking symptoms, but a profound alteration in the sense of Self. Bleuler, in fact, considered Self-Disturbances to be…

Video (in Spanish) On October 30th, at our SUCEDE seminar, we dedicated the bibliographic session to a study that introduces a fundamental modification to the Corollary Discharge paradigm. As you know, we’ve been investigating Corollary Discharge as a key mechanism for action source attribution—that is, for distinguishing what we do ourselves from what occurs in…

Video of the meeting (in Spanish, English subtitles) Psychosis Biotypes: Why Neurobiology Trumps Clinical Labels In our last session, we dissected a fundamental article by the Clements Group (2019) that challenges the way we classify psychosis. The central thesis: traditional clinical diagnoses (like those in the D S M) generate great heterogeneity and overlap among…

On ivoox, Spotify and Amazon Recently, Professor Vicente Molina, Principal Investigator of our SUCEDE group, took part in a fantastic interview and conversation on the Psiquiatras CON ciencia podcast. The introduction, led by host José María Pelayo, took us back to the origins of the Electroencephalogram (EEG), a crucial technique in our work. He reminded…

Video of the meeting Ipseity in Schizophrenia: Towards a Definition of Valid Biotypes The recent doctoral thesis defense rehearsal, presented by Marta Hernández from the SUCEDE – Sustratos Cerebrales de la Psicosis (Cerebral Substrates of Psychosis) team, addresses a crucial paradigm shift in the study of schizophrenia. The work is titled “Neurocognitive assessment, anomalous self-experiences…

We attended the 38th Congress of the European College of Neuropsychopharmacology (ECNP) | 11–14 October 2025 | Amsterdam, The Netherlands | with the following presentation: ‘Differences in resting-state spectral power between psychosis cognitive subgroups and healthy controls across frequency bands’ (Osorio-Iriarte et al., 2025)

Video of the meeting Uncovering Schizophrenia Biotypes: The Path to Therapeutic Precision The SUCEDE research group’s work has focused on breaking down the heterogeneity of schizophrenia by identifying distinct cerebral biotypes, aiming to overcome the limitations of symptom-only diagnoses. Early studies, dating back to 1996, observed that schizophrenia patients who responded effectively to the drug…

Video SUCEDE meeting (in Spanish) The Neurobiological Heterogeneity of Depression (SUCEDE Bibliographic Session)The premise of the session is that Major Depression (MD) is not a uniform illness. Its symptoms are highly heterogeneous, encompassing emotional categories (sadness, guilt), anxiety categories (rumination, irritability), and somatic categories (alterations in appetite, sleep, and energy). This symptomatic variety suggests that…