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ANOMALOUS EXPERIENCES OF THE SELF AND CONSEQUENT DISCHARGE IN SCHIZOPHRENIA. STATUS OF OUR PROJECT BY ROSA BEÑO (PHD CANDIDATE). Corollary discharge (CD) has been studied in several sensory-perceptual phenomena. This is a mechanism used to distinguish self-generated perceptions from those coming from external sources, allowing us to label the sensations that come from acts generated…

Today our colleague from the Hospital Clínico Universitario de Valladolid, Dr. Óscar Martín, summarizes his literature review of the article: “Heterogeneity of Striatal Dopamine Function in Schizophrenia: Meta-analysis of Variance” (Stefan P. Brugger et al.; Biol Psychiatry, 2020). Alterations of dopamine function in schizophrenia have been proven since the beginning of neuroleptic treatment in the…

JOURNAL CLUB: NEURONAL NETWORKS AND COGNITIVE ALTERATIONS IN PSYCHIATRIC DISORDERS (EVA RODRÍGUEZ VÁZQUEZ MIR-IV PSYCHIATRY HCUV) It has long been assumed that cognitive functions are attributed to isolated brain areas. In the last decade, more and more studies have been based on the idea that cognition is the result of dynamic interactions of brain areas…

ALTERATIONS IN EEG ACTIVITY DURING AN N-BACK TASK IN SCHIZOPHRENIA (DR. ANTONIO ARJONA) In the last two decades there has been a significant increase in the number of publications that highlight deficits in working memory as a central factor within the cognitive symptomatology associated with schizophrenia (Sz). However, there is still a wide lack of…

Today our colleague Rosa Beño summarizes and presents a key review on Speaking-Induced Suppression (SIS), key to understand the alterations of the self in patients with schizophrenia. BILIOGRAPHIC REVIEW: Whitford, T. J. (2019). Speaking-induced suppression of the auditory cortex in humans and its relevance to schizophrenia. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 4(9), 791-804.            …

Groupings of patients with schizophrenia and bipolar disorder based on EEG functional network measures (Vicente Molina and Alvaro Planchuelo) We have analyzed the possibility of describing biologically valid clusters of patients with schizophrenia and bipolar disorder based on the characteristics of their functional network derived from EEG recordings. We found two clusters: with this altered…

PATIENTS WITH GREATER HYPERACTIVATION AT RESTING STATE MODULATE THEIR BRAIN ACTIVITY LESS DURING A COGNITIVE TASK. EVIDENCE USING THE SPECTRAL ENTROPY MEASURE (Dr. María Iglesias and Dr. Álvaro Díez) Entropy is a thermodynamic function that was adapted to the context of information theory.  Applied in the power spectrum of the EEG it is called Spectral…

BIBLIOGRAPHIC REVIEW: IMPAIRED COROLLARY DISCHARGE IN PSYCHOSIS AND AT-RISK STATES: INTEGRATING NEURODEVELOPMENTAL, PHENOMENOLOGICAL AND CLINICAL PERSPECTIVES (Poletti et al., 2019, Biol Psychiatry Cogn Neurosci Neuroimaging). In this article published in 2019 in Biol Psychiatry Cogn Neurosci Neurimaging, the authors (Michele Poletti, Antonio Tortorella and Andrea Raballo) start from the following conceptual framework: they understand the…

PRELIMINARY RESULTS: ALTERATIONS IN COROLLARY DISCHARGE IN SCHIZOPHRENIA Corollary discharge (CD) is a mechanism used to distinguish self-generated perceptions from those coming from external sources. To correctly make this distinction, a copy of the motor processing is sent to the sensory regions, predicting the sensory consequences that this motor act will generate. By comparing this…

General Cognition and Alteration in Self-experiences in Schizophrenia Abnormal Self-experiences (ASEs) are prevalent in patients with schizophrenia, even though it is considered a primary alteration in this mental illness. Although understanding of these abnormal experiences is still poor, it seems conceivable that those ASEs may be related to other altered functions in psychosis that require…