The understanding of schizophrenia has evolved from mere symptomatic observation toward the search for biological substrates that explain the alteration of the “Self.” In our latest seminar session, Antonio Arjona, a researcher at SUCEDE, presented the most recent advances in his project focused on corollary discharge (CD) and readiness potential.
Corollary discharge is an essential neurophysiological mechanism that allows the brain to predict the sensory consequences of our own actions. In patients within the psychotic spectrum, this mechanism often fails, making it difficult to distinguish between internally generated signals and external stimuli. Arjona delves into how these anomalies in the prediction signal relate to “anomalous self-experiences”—subtle changes in ipseity that often precede overt clinical symptoms.
The data presented suggest that alterations in functional connectivity and motor speech preparation could serve as early biomarkers, offering a unique window into understanding the fragmentation of subjective experience in psychosis.
Watch the full session here: https://youtu.be/eXah74gFgJM