PRELIMINARY ANALYSIS OF RESTING-STATE CORRELATIONS fMRI – IPASE
(Dr. Álvaro Planchuelo; video: https://youtu.be/VTswA__Nu_0)
Preliminarily, the relationship between functional connectivity measured from resting functional magnetic resonance imaging (rs-fMRI) and anomalous experiences of the self is proposed.
The starting hypothesis is that increased resting functional activity (inhibition deficit) in patients with schizophrenia is linked to increased abnormal experience. Therefore, to examine the hypothesis, correlations between IPASE scores and each pair of functional connections between regions forming the default neural network are analyzed. The default neural network is a set of gray matter regions that show increased activation in the “resting state”, when no particular activity is performed.
The first results of the analysis show that, at a general level, greater functional connectivity between the regions of the default neural network is linked to higher scores on the IPASE scale, i.e., greater abnormal experience of the self. On the other hand, for the cognition subscale, the opposite trend was detected, higher functional connectivity related to lower IPASE scores, in connections with the orbitofrontal cortex or the rostral anterior cingulate gyrus.